Behind the Science
Shauna McManus
Shauna McManus is a Senior Research Analyst in Patient-Centered Outcomes & Engagement, located in the Bethesda, MD office. Her expertise includes quantitative research and the development and psychometric validation of patient-reported outcome measures. Prior to joining OPEN Health, Shauna worked as a Research Manager at the Cancer Support Community’s Research and Training Institute, analyzing patient and caregiver data in order to better understand patient perspectives, preferences, and unmet needs.
ISPOR 2022 Podium Presentation
Although recent FDA oncology guidance has emphasized the importance of an anchor-based approach for estimating thresholds of meaningful within-patient change (MWPC), there is little published work reporting results based on the implementation of this approach for legacy instruments.
Watch the recording to learn more about this research presented at ISPOR Europe 2022.
Shauna McManus is involved in the following poster presentation at ISPOR US 2023:
ISPOR US 2023 Poster
A Time-to-Event Framework for Quantifying Clinical Significance of Effect in Alzheimer’s Disease Clinical Trials
Alzheimer’s Disease (AD) is a progressive neurodegenerative disease associated with significant costs. Many AD therapeutic trials fail to demonstrate clinical significance. This work presents a method for reframing clinical significance in terms of a meaningful delay in time to the level of cognitive functioning associated with substantial new costs.
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