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Behind the Science

Elisabeth Fenwick

Elisabeth Fenwick is Deputy Chief Scientific Officer for Evidence & Access, located in the Oxford, UK, office. She provides scientific and strategic support to health economics projects globally and has extensive experience in economic evaluation and health economic modeling, having worked in the field for over 20 years.

Novel Oncology Therapies Require Innovative Methods in Oncology Modeling

Innovative methods in oncology modeling are needed to demonstrate the value of many new cancer treatments, including immuno-oncologic therapies.

Health technology assessment (HTA) agencies have long required evidence of long-term survival and lifetime estimates of quality of life before they will approve new treatments. Health economics and outcomes research analysts have relied on standard parametric models to extrapolate overall survival rates from clinical trial data to estimate quality of life.

This traditional approach identifies the statistical models that best fit the available data and then uses these models to predict outcomes over the lifetime. It worked well for traditional cancer treatments, including chemotherapy. However, many new oncology drugs have a different mechanism of action—including the possibility of delayed and prolonged response to treatment and, potentially, cure—which may not be accurately represented by these traditional models.

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Elisabeth Fenwick is involved in the following short course at ISPOR US 2023:

Advanced Decision Modeling for Health Economic Evaluations

During this in-person short course at the ISPOR US 2023, the key aspects and new developments of decision modeling for economic analysis will be considered. In particular, we will explore how the limitations of Markov models can be overcome using various modeling techniques, including different options for introducing time-dependency into state transition models.

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Other resources

Visit these other resources to find out more about Elisabeth Fenwick's research and work

Novel Approaches to Plugging Data Gaps

An article in OPEN Health's ISPOR US Journal 2022

Publication Library

View all the publications on the OPEN Health website

Other resources

Visit these other resources to find out more about Elisabeth Fenwick's research and work

Novel Approaches to Plugging Data Gaps

An article in OPEN Health's ISPOR US Journal 2022

Publication Library

View all the publications on the OPEN Health website